Glycine → 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboamide

HRID 894196노트

반응식

HRID 894196 반응식
Cl[C:2]([C:4]1[CH:19]=[CH:18][C:7]2[O:8][CH2:9][C:10]3[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=3[C:12](=[O:13])[C:6]=2[CH:5]=1)=[O:3].[NH2:20]CC(O)=O>C(OCC)(=O)C>[O:13]=[C:12]1[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[CH2:9][O:8][C:7]2[CH:18]=[CH:19][C:4]([C:2]([NH2:20])=[O:3])=[CH:5][C:6]1=2

참가 물질

4

반응물 2

HCID 750GlycineHCID 134560052-Chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin

생성물 1

HCID 124468236,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Reflux 1.0 gm of 2-chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin in 20 cc of ethyl acetate containing 2.0 gm of glycine for 5 hours. Evaporate the mixture to dryness. Add 30 cc of water to the solid residue and stir at room temperature for one hour. Separate the solid by filtration and recrystallize from ethanol to obtain the title product.

후처리

  1. customEvaporate the mixture to dryness
  2. additionAdd 30 cc of water to the solid residue
  3. customSeparate the solid
  4. filtrationby filtration
  5. customrecrystallize from ethanol

출처 및 근거

ORD 기록
ord-d38d92c749664713907e853bf6c5d659
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04282365

반응 노트

불러오는 중…