3-Hydroxypropionic acid → beta-Carboxyethyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylate

HRID 894197노트

반응식

HRID 894197 반응식
Cl[C:2]([C:4]1[CH:19]=[CH:18][C:7]2[O:8][CH2:9][C:10]3[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=3[C:12](=[O:13])[C:6]=2[CH:5]=1)=[O:3].[Na].[OH:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25]>O1CCCC1>[O:13]=[C:12]1[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[CH2:9][O:8][C:7]2[CH:18]=[CH:19][C:4]([C:2]([O:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[O:3])=[CH:5][C:6]1=2

참가 물질

5

반응물 3

HCID 681523-Hydroxypropionic acidHCID 5360545SodiumHCID 134560052-Chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin

생성물 1

HCID 21162729beta-Carboxyethyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Dissolve 1.0 gm of 2-chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin in 20 cc of tetrahydrofuran and add 1.0 gm of the sodium salt of β-hydroxypropionic acid. Stir the mixture at room temperature for 18 hours. Filter and evaporate the filtrate to dryness. Recrystallize the solid residue from ethanol to obtain the title product.

후처리

  1. filtrationFilter
  2. customevaporate the filtrate to dryness
  3. customRecrystallize the solid residue from ethanol

출처 및 근거

ORD 기록
ord-1bf56c2a8e9b47169a1b159c92fee450
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04282365

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