Acetic Acid → 6,11-Dihydro-11-ethylidenedibenz[b,e]oxepin-2-carboxylic Acid

HRID 894222노트

반응식

HRID 894222 반응식
C(C1[CH:19]=[CH:18][C:6]2[O:7][CH2:8][C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[C:11](=[CH:12][CH3:13])[C:5]=2[CH:4]=1)#N.[C:20]([OH:23])(=[O:22])[CH3:21].Cl>O>[CH:12](=[C:11]1[C:10]2[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=2[CH2:8][O:7][C:6]2[CH:18]=[CH:19][C:21]([C:20]([OH:23])=[O:22])=[CH:4][C:5]1=2)[CH3:13]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 536734252-Cyano-6,11-dihydro-11-ethylidenedibenz[b,e]oxepin

생성물 1

HCID 545396956,11-Dihydro-11-ethylidenedibenz[b,e]oxepin-2-carboxylic Acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Reflux a mixture of 2.8 gm of the nitrile of Step A, 50 ml of acetic acid, 5 ml of water and 5 ml of concentrated hydrochloric acid for 140 hours. Cool the reaction mixture, separate the solids by filtration and dry. Recrystallize from toluene to obtain the title product.

후처리

  1. temperatureReflux
  2. temperatureCool the reaction mixture
  3. customseparate the solids
  4. filtrationby filtration
  5. customdry
  6. customRecrystallize from toluene

출처 및 근거

ORD 기록
ord-e65d07c7de3d4a0dbf28170e3b422d46
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04282365

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