Hydrochloric Acid → alpha-Fluoro-alpha-isopropyl-4-chlorophenylacetic acid

HRID 894341노트

반응식

HRID 894341 반응식
[F:1][C:2]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)([CH:8]([CH3:10])[CH3:9])[C:3]([O:5]CC)=[O:4].[OH-].[K+].Cl>CO.O>[F:1][C:2]([C:11]1[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=1)([CH:8]([CH3:10])[CH3:9])[C:3]([OH:5])=[O:4]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13194588Ethyl alpha-fluoro-alpha-isopropyl-4-chlorophenylacetate

생성물 1

HCID 13194589alpha-Fluoro-alpha-isopropyl-4-chlorophenylacetic acid수율 87%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A mixture of ethyl α-fluoro-α-isopropyl-4-chlorophenylacetate (1.42 g) and potassium hydroxide (0.35 g) in methanol (5 ml) was stirred at ambient temperature for 2.5 hours. The reaction mixture was acidified with hydrochloric acid, diluted with water and the aqueous mixture extracted with methylene chloride. The methylene chloride extract was dried over anhydrous sodium sulfate and the solvent removed by distillation under reduced pressure to give α-fluoro-α-isopropyl-4-chlorophenylacetic acid (1.10 g; 87%) m.p. 120° C.

후처리

  1. extractionthe aqueous mixture extracted with methylene chloride
  2. extractionThe methylene chloride extract
  3. dry with materialwas dried over anhydrous sodium sulfate
  4. customthe solvent removed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-227d77cfd16a4210b6a86024796c7b0c
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04283414

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