Hydrochloric Acid → HCID 13388353, 화합물

HRID 894664노트

반응식

HRID 894664 반응식
[CH3:1][C:2]1[NH:3][C:4]([CH:27](OCC)[O:28]CC)=[C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].Cl>CC(C)=O>[CH3:1][C:2]1[NH:3][C:4]([CH:27]=[O:28])=[C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 15737353HCID 15737353, 화합물

생성물 1

HCID 13388353HCID 13388353, 화합물수율 92.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of diethyl 2-methyl-4-(3-nitrophenyl)-6-diethoxymethyl-1,4-dihydropyridine-3,5-dicarboxylate (462.5 mg) in acetone (4 ml) was added 6N-hydrochloric acid (0.4 ml) and stirred at room temperature for an hour. After the reaction, the solvent was removed from the resultant solution. To the residue was added water, and the residue was pulverized. The powder was collected by filtration, washed with water and dried to give diethyl 2-methyl-4-(3-nitrophenyl)-6-formyl-1,4-dihydropyridine-3,5-dicarboxylate (360 mg), m.p. 130° to 133° C.

후처리

  1. customAfter the reaction
  2. customthe solvent was removed from the resultant solution
  3. additionTo the residue was added water
  4. filtrationThe powder was collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-f6f68336c65d44deb6bdb85c20bde9bc
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04284634

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