HCID 3645909, 화합물 → HCID 178435023, 화합물
반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[C:10]([CH3:11])=[C:9]([CH3:12])[S:8][C:6]=2[N:7]=1.[BH4-].[Na+]>C(O)C.C(Cl)(Cl)Cl>[Cl:1][C:2]1[NH:3][CH2:4][C:5]2[C:10]([CH3:11])=[C:9]([CH3:12])[S:8][C:6]=2[N:7]=1참가 물질
4
실험 절차
To a solution of 4.66 g of 2,4-dichloro-5,6-dimethylthieno[2,3-d]pyrimidine in 150 ml of ethanol-chloroform (1:1 by volume) was slowly added 2.32 g of sodium borohydride with stirring. The mixture was stirred at room temperature for 6 hours and the solvent removed in vacuo. To the solid residue was added 50 ml of water and the insoluble material was filtered, washed with water, dried, and recrystallized from benzene to give 2.05 g of 2-chloro-5,6-dimethyl-3,4-dihydrothieno[2,3-d]pyrimidine, mp 170°-172° C.
후처리
- stirringThe mixture was stirred at room temperature for 6 hours
- customthe solvent removed in vacuo
- additionTo the solid residue was added 50 ml of water
- filtrationthe insoluble material was filtered
- washwashed with water
- customdried
- customrecrystallized from benzene
출처 및 근거
- ORD 기록
- ord-4e42bcc474f14d85ae1c31f9f5806486
- 출처 데이터셋
- uspto-grants-1981_08
- 특허 번호
- US04284773
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