Diethyl Ether → 2-(3-Methoxyphenyl)-2-methyloxirane

HRID 894918노트

반응식

HRID 894918 반응식
[CH3:1]S(C)(=O)=C.CO[CH:8](OC)[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].C[CH2:20][O:21]CC>CS(C)=O.O>[CH3:20][O:21][C:15]1[CH:16]=[C:11]([CH:12]=[CH:13][CH:14]=1)[C:9]1([CH3:8])[O:10][CH2:1]1

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 2483332,2-Dimethoxy-1-phenylethanoneHCID 6396768Dimethylsulfoxonium methylide

생성물 1

HCID 204969162-(3-Methoxyphenyl)-2-methyloxirane

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

To a solution of dimethylsulfoxonium methylide (69.4 mmoles) in dimethyl sulfoxide (65 ml.) at room temperature is added solid 3-l -dimethoxyacetophenone (8.33 g., 55.5 mmoles). The reaction mixture is stirred for one hour at 25° C., for one-half hour at 50° C. and is then cooled. The mixture is diluted with water (50 ml.) and added to a mixture of ice water (200 ml.)--ether (250 ml.)--low boiling petroleum ether (25 ml.). The organic extract is washed twice with water (250 ml.), dried (MgSO4) and evaporated to an oil which is fractionally distilled.

후처리

  1. temperatureis then cooled
  2. extractionThe organic extract
  3. washis washed twice with water (250 ml.)
  4. dry with materialdried (MgSO4)
  5. customevaporated to an oil which
  6. distillationis fractionally distilled

출처 및 근거

ORD 기록
ord-23b5d1020e8f4ab59f87e7356365424b
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04284829

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