Piperidine → N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide

HRID 895476

반응식

HRID 895476 반응식
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[N:9]=[C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=1)=[O:4].[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C>[Cl:12][C:10]1[N:9]=[C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:11]=1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 223791512-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide

생성물 1

HCID 22353518N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

2-Bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (28 mg) was dissolved in acetonitrile (2 ml) and piperidine added (23 μl in 500 ul acetonitrile). The mixture was left to stir for 1.5 hr after which time the solvent was removed in vacuo. Purification using a short silica plug, eluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v) furnished the title compound (25 mg).

후처리

  1. waitThe mixture was left
  2. customwas removed in vacuo
  3. customPurification
  4. washeluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v)

출처 및 근거

ORD 기록
ord-ad95920473d8498281b9e63a8038cdd2
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06916804B2

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