Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide | HCID 22379151 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide | HCID 22353518 | — |
반응 단계
2-Bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (28 mg) was dissolved in acetonitrile (2 ml) and piperidine added (23 μl in 500 ul acetonitrile). The mixture was left to stir for 1.5 hr after which time the solvent was removed in vacuo. Purification using a short silica plug, eluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v) furnished the title compound (25 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06916804B2 |
| 출처 데이터셋 | uspto-grants-2005_07 |
| ORD ID | ord-ad95920473d8498281b9e63a8038cdd2 |
| 출처 메모 | uspto-grants-2005_07 |