Hydrochloric Acid → HCID 178516641, 화합물

HRID 895488

반응식

HRID 895488 반응식
[O-]CC.[Na+].[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[NH:11])=[CH:8][CH:7]=1.[C:15](OCC)(=[O:22])[CH2:16][C:17](OCC)=[O:18].Cl>C(O)C>[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]2[N:12]=[C:17]([OH:18])[CH:16]=[C:15]([OH:22])[N:11]=2)=[CH:8][CH:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 2034374-ChlorobenzamidineHCID 2723922Sodium ethoxide

생성물 1

HCID 178516641HCID 178516641, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
40 °C

실험 절차

To sodium ethoxide (48 ml of a 21% wt solution in ethanol diluted with a further 130 ml ethanol) was added 4-chlorobenzamidine (8 g) and diethyl malonate (6.67 ml) and the solution left to stir at 40° C. for 96 hrs. The reaction mixture was subsequently cooled to 5° C. and acidified cautiously to pH 2 using concentrated hydrochloric acid. The solid thus precipitated was filtered, washed with excess cold water, then 50 ml diethyl ether and dried in vacuo yielding the title compound (7.51 g).

후처리

  1. waitthe solution left
  2. temperatureThe reaction mixture was subsequently cooled to 5° C.
  3. customThe solid thus precipitated
  4. filtrationwas filtered
  5. washwashed with excess cold water
  6. dry with material50 ml diethyl ether and dried in vacuo

출처 및 근거

ORD 기록
ord-7724f17f420741168f75f8b88270b3d2
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06916804B2

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