Nitric Acid → 4-(Benzyloxy)-5-methoxy-2-nitrobenzonitrile

HRID 896255노트

반응식

HRID 896255 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:6]#[N:7].[N+:19]([O-])([OH:21])=[O:20].[K]>C(O)(=O)C>[N+:19]([C:8]1[CH:9]=[C:10]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[C:6]#[N:7])([O-:21])=[O:20]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 7937714-Benzyloxy-3-methoxy-benzonitrileHCID 5462222Potassium

생성물 1

HCID 116736184-(Benzyloxy)-5-methoxy-2-nitrobenzonitrile수율 64%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3-methoxy-4-benzyloxybenzonitrile (4.78 g, 20 mmol) in acetic acid (10 ml) was slowly added to nitric acid (d=1.42, 25 ml) at 20-30° with cooling in an ice bath. The mixture was then stirred at room temperature for 6 hours. The reaction mixture was treated with potassium hydroxyde (10N) at 0° C. The basic mixture (pH 10) was extracted with CH2Cl2, the organic phase was dried over MgSO4, concentrated to give title compound (3.62 g, 64%).

후처리

  1. temperaturewith cooling in an ice bath
  2. extractionThe basic mixture (pH 10) was extracted with CH2Cl2
  3. dry with materialthe organic phase was dried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cd1df245d14641e1ba3927a52ac134cd
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06919338B2

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