Dimethylformamide dimethyl acetal → N'-(2-cyano-4-methoxy-5-benzyloxyphenyl)-N,N-dimethylimidoformamide
반응식
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:7]([O:18][CH3:19])=[CH:6][C:3]=1[C:4]#[N:5].[CH3:20][N:21]([CH:23](OC)OC)[CH3:22]>C1(C)C=CC=CC=1>[C:4]([C:3]1[CH:6]=[C:7]([O:18][CH3:19])[C:8]([O:10][CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:9][C:2]=1[N:1]=[CH:20][N:21]([CH3:23])[CH3:22])#[N:5]참가 물질
4
실험 절차
2-amino-4-benzyloxy-5-methoxy benzonitrile (102 g, 400 mmol) in toluene (1.51) was reacted with DMF-DMA (110 ml, 780 mmol) at reflux for 5 hours. The solvent was evaporated, the residue triturated with ether to give title compound as yellow solid.
후처리
- temperatureat reflux for 5 hours
- customThe solvent was evaporated
- customthe residue triturated with ether
출처 및 근거
- ORD 기록
- ord-395d8c12acfd43f092278532e885aad7
- 출처 데이터셋
- uspto-grants-2005_07
- 특허 번호
- US06919338B2
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