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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → [2-(3-cyclopropyl-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester

HRID 896346
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HRID 896346 반응식
[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]2=[O:15])[CH2:3][CH2:2]1.CC(N=P(N1CCCC1)(N1CCCC1)N1CCCC1)(C)C.[C:37]([O:41][C:42](=[O:61])[NH:43][CH2:44][C:45]1[CH:60]=[CH:59][C:48]2[N:49]([CH2:54][CH2:55][CH:56]([CH3:58])[CH3:57])[C:50]([CH2:52]Cl)=[N:51][C:47]=2[CH:46]=1)([CH3:40])([CH3:39])[CH3:38].Cl>CN(C=O)C>[C:37]([O:41][C:42](=[O:61])[NH:43][CH2:44][C:45]1[CH:60]=[CH:59][C:48]2[N:49]([CH2:54][CH2:55][CH:56]([CH3:57])[CH3:58])[C:50]([CH2:52][N:6]3[C:7]4[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:13](=[O:14])[N:4]([CH:1]4[CH2:3][CH2:2]4)[C:5]3=[O:15])=[N:51][C:47]=2[CH:46]=1)([CH3:38])([CH3:40])[CH3:39]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3856267tert-Butylimino-tri(pyrrolidino)phosphoraneHCID 172214493-cyclopropyl-1H-quinazoline-2,4-dioneHCID 59561810HCID 59561810, 화합물

생성물 1

HCID 69718855[2-(3-cyclopropyl-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester수율 80%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of the 3-cyclopropyl-1H-quinazoline-2,4-dione (148 mg, 0.73 mmol) in DMF (10 mL) was added BTPP (684 mg, 2.19 mmol). After stirring for 20 minutes, [2-chloromethyl-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester; HCl salt (294 mg, 0.73 mmol) was added and the resulting mixture was stirred at room temperature overnight. The solvent was removed in vacuo and the residue precipitated from water. The title compound was collected by filtration and extensively washed with water and dried in vacuo to yield [2-(3-cyclopropyl-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester as an off-white solid (310 mg, 80%):

후처리

  1. stirringthe resulting mixture was stirred at room temperature overnight
  2. customThe solvent was removed in vacuo
  3. customthe residue precipitated from water
  4. filtrationThe title compound was collected by filtration
  5. washextensively washed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-416c61d600ae4d5dafd6bb752c73ab04
출처 데이터셋
uspto-grants-2005_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06919331B2

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