2-Nitrobenzenesulfonyl chloride → N-cyclopropyl-2-nitrobenzenesulfonamide

HRID 896348

반응식

HRID 896348 반응식
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[N+:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14](Cl)(=[O:16])=[O:15])([O-:7])=[O:6]>C(Cl)Cl>[CH:1]1([NH:4][S:14]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N+:5]([O-:7])=[O:6])(=[O:15])=[O:16])[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 155402-Nitrobenzenesulfonyl chlorideHCID 69828Cyclopropylamine

생성물 1

HCID 796630N-cyclopropyl-2-nitrobenzenesulfonamide수율 88%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a −78° C. mixture of cyclopropylamine (10 g, 1.75 mmol) in CH2Cl2 (100 mL) was added a solution of 2-nitrobenzene sulfonyl chloride (22.1 g, 85.7 mmol) and the mixture was stirred for 12 h. The mixture was washed with 1N HCl dried over MgSO4 then concentrated to give 18.7 g, (88%) of a N-Cyclopropyl-2-nitro-benzenesulfonamide as a tan solid.

후처리

  1. washThe mixture was washed with 1N HCl
  2. dry with materialdried over MgSO4
  3. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-56ffc089fbf04dcbbaa076fcefc8b31e
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06919331B2

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