Tetramethylammonium hydroxide → Lipoic acid

HRID 896940

반응식

HRID 896940 반응식
[OH-].C[N+](C)(C)C.CC(C)([O-])C.[K+].[CH2:13]([CH2:19][C@@H:20]([SH:24])[CH2:21][CH2:22][SH:23])[CH2:14][CH2:15][C:16]([OH:18])=[O:17]>CN(C=O)C>[CH2:21]1[C@@H:20]([CH2:19][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[S:24][S:23][CH2:22]1.[CH2:13]([CH2:19][C@@H:20]([SH:24])[CH2:21][CH2:22][SH:23])[CH2:14][CH2:15][C:16]([OH:18])=[O:17]

참가 물질

6

반응물 3

HCID 60966Tetramethylammonium hydroxideHCID 9834298(R)-Dihydrolipoic acidHCID 23665647Potassium tert-butoxide

생성물 2

HCID 6112Lipoic acidHCID 9834298(R)-Dihydrolipoic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In other synthetic schemes the base, tetramethylammonium hydroxide can be substituted for potassium t-butoxide in DMF. The former base though can be stored under air, whilst the latter needs to be kept in an inert atmosphere. The dihydrolipoic acid works best if it totally clear. If the reduction lipoic acid to produce dihydrolipoic acid is not complete, a yellow coloration of the solution will be evident. The yellow solution can be distilled (distills at 140° C. under vacuum) to yield a clear solution of dihydrolipoic acid.

출처 및 근거

ORD 기록
ord-dfa8a8fbcaf8412da0e392ebd82dc423
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06921496B2

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