Sodium borohydride → (1-benzyl-4-chloro-2-(4-nitrophenyl)-1H-imidazol-5-yl)methanol

HRID 896945노트

반응식

HRID 896945 반응식
[BH4-].[Na+].[CH2:3]([N:10]1[C:14]([CH:15]=[O:16])=[C:13]([Cl:17])[N:12]=[C:11]1[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[CH2:3]([N:10]1[C:14]([CH2:15][OH:16])=[C:13]([Cl:17])[N:12]=[C:11]1[C:18]1[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[CH:22][CH:23]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydride2회HCID 150885051-benzyl-4-chloro-2-(4-nitrophenyl)-1H-imidazole-5-carbaldehyde

생성물 1

HCID 15088539(1-benzyl-4-chloro-2-(4-nitrophenyl)-1H-imidazol-5-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium borohydride (1.1 g, 29 mmole) was added in three portions to a stirred mixture of crude 1-benzyl-4-chloro-5-formyl-2-(4-nitrophenyl)imidazole (54.2 g, 88 mmole) in methanol (250 ml) at room temperature. After two hours, more sodium borohydride (0.51 g, 15 mmol) was added, the mixture was stirred for 30 minutes and the methanol was evaporated. The residue was mixed with water (250 ml) and extracted with methylene chloride (200 ml, 3×50 ml). The combined organic solutions were washed with water (2×50 ml) and dried (NaSO4) overnight.

후처리

  1. customthe methanol was evaporated
  2. additionThe residue was mixed with water (250 ml)
  3. extractionextracted with methylene chloride (200 ml, 3×50 ml)
  4. washThe combined organic solutions were washed with water (2×50 ml)
  5. dry with materialdried (NaSO4) overnight

출처 및 근거

ORD 기록
ord-e686edc2b26845369706b226ea9640f9
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06921525B2

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