Hydrochloric Acid → 1-Bromo-4-(1-ethoxyethoxy)benzene

HRID 896952노트

반응식

HRID 896952 반응식
[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2].[CH:7]1[C:12](O)=[CH:11][CH:10]=[C:9]([Br:14])[CH:8]=1.Cl.C(OC=C)C>CCOCC>[CH2:5]([O:4][CH:1]([O:3][C:12]1[CH:11]=[CH:10][C:9]([Br:14])=[CH:8][CH:7]=1)[CH3:2])[CH3:6]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 78084-BromophenolHCID 8023Ethyl vinyl etherHCID 8857Ethyl Acetate

생성물 1

HCID 27237611-Bromo-4-(1-ethoxyethoxy)benzene

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Into 100 ml of dehydrated ethyl acetate, were fed 11.0 g (50 mmol) of p-bromophenol, and 4.8 ml of a solution composed of hydrochloric acid (1.0 mol/L) and ether, and the mixture was set at 40° C. Into the mixture, 10.8 g (150 mmol) of ethylvinylether was added dropwise, and the mixture was kept with stirring for one night. After completion of the reaction, the reaction solution was rinsed with sodium hydrogen carbonate solution and then rinsed with water to remove solvent. By purifying with silica gel column chromatography (eluate: hexane), 10.7 g (36.5 mmol) of 1-(1-ethoxy)ethoxy-4-bromobenzene was obtained.

후처리

  1. customwas set at 40° C
  2. customAfter completion of the reaction
  3. washthe reaction solution was rinsed with sodium hydrogen carbonate solution
  4. washrinsed with water
  5. customto remove solvent
  6. customBy purifying with silica gel column chromatography (eluate: hexane)

출처 및 근거

ORD 기록
ord-ffd1f9421537494f826ee392e6c85942
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06921623B2

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