Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 5-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)pentyl Acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Bromopentyl acetate | HCID 85140 | — |
| 반응물 | 3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 10779311 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)pentyl Acetate | HCID 22252775 | — |
반응 단계
A solution of 3-bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol (10 g, 0.35 mol), 5-bromopentyl acetate (8.15 g) and potassium carbonate (33.6 g) in methyl ethyl ketone (200 ml) is refluxed for 2 hours. The reaction medium is treated with water and ethyl acetate. After separation of the phases by settling, the organic phase is washed twice with water, dried over magnesium sulphate and concentrated on a rotary evaporator under vacuum at 40° C. The product is purified by flash chromatography on a column of silica.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06921777B2 |
| 출처 데이터셋 | uspto-grants-2005_07 |
| ORD ID | ord-88a8d2ce6fd74a33a3f31ab483d92a26 |
| 출처 메모 | uspto-grants-2005_07 |