反应详情

A solution of 3-bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol (10 g, 0.35 mol), 5-bromopentyl acetate (8.15 g) and potassium carbonate (33.6 g) in methyl ethyl ketone (200 ml) is refluxed for 2 hours. The reaction medium is treated with water and ethyl acetate. After separation of the phases by settling, the organic phase is washed twice with water, dried over magnesium sulphate and concentrated on a rotary evaporator under vacuum at 40° C. The product is purified by flash chromatography on a column of silica.

1. customAfter separation of the phases
2. washthe organic phase is washed twice with water
3. dry with materialdried over magnesium sulphate
4. concentrationconcentrated on a rotary evaporator under vacuum at 40° C
5. customThe product is purified by flash chromatography on a column of silica