3,4-Dihydroxybenzaldehyde → 4-Hydroxy-3-propoxybenzaldehyde
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].[H-].[Na+].I[CH2:14][CH2:15][CH3:16]>CN(C=O)C.C(OCC)(=O)C>[OH:10][C:9]1[CH:8]=[CH:7][C:4]([CH:5]=[O:6])=[CH:3][C:2]=1[O:1][CH2:14][CH2:15][CH3:16]참가 물질
6
실험 절차
3,4-Dihydroxybenzaldehyde (0.5 g, 3.62 mmol) was dissolved in DMF (10 mL) and sodium hydride (0.087 g, 3.62 mmol) was added. The reaction mixture was stirred at rt for 10 min. Iodopropane (0.35 mL, 0.62 mmol) was added and the reaction was stirred at 80° C. for 2.5 h. The reaction was diluted with ethyl acetate and washed with 2N HCl and water. Silica gel chromatography eluting with 35% ethyl acetate/hexane yielded 0.16 g of desired product: ESI-MS 181 (M+H).
후처리
- stirringthe reaction was stirred at 80° C. for 2.5 h
- washwashed with 2N HCl and water
- washSilica gel chromatography eluting with 35% ethyl acetate/hexane
출처 및 근거
- ORD 기록
- ord-cbab7b2cf3c546d3a9c078fecfbbfae0
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07351725B2
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