6-Methoxy-2-naphthaldehyde → 6-Hydroxy-2-naphthaldehyde
반응식
[Cl-].[Cl-].[Cl-].[Al+3].C[O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2>ClC1C=CC=CC=1>[OH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2참가 물질
4
반응 조건
- 온도
- 130 °C
실험 절차
Aluminum trichloride (1.07 g, 8.06 mmol) was added to a solution of 6-methoxy-2-naphthaldehyde (1.0 g, 5.37 mmol) in chlorobenzene (15 mL). The reaction mixture was stirred at 130° C. for 4 h. The reaction was quenched with water (5 mL) and conc. HCl (2 mL). The reaction mixture was dissolved in ethyl acetate and washed with water and brine and dried over anhydrous magnesium sulfate. Silica gel chromatography eluting with 10% ethyl acetate/hexane yielded 0.35 g of desired product: ESI-MS173.0 (M+H).
후처리
- customThe reaction was quenched with water (5 mL) and conc. HCl (2 mL)
- dissolutionThe reaction mixture was dissolved in ethyl acetate
- washwashed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- washSilica gel chromatography eluting with 10% ethyl acetate/hexane
출처 및 근거
- ORD 기록
- ord-89c00d81e8fb4583825a73f1263c7bee
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07351725B2
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