6-Methoxy-2-naphthaldehyde → 6-Hydroxy-2-naphthaldehyde

HRID 898188

반응식

HRID 898188 반응식
[Cl-].[Cl-].[Cl-].[Al+3].C[O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2>ClC1C=CC=CC=1>[OH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2

참가 물질

4

반응물 2

HCID 769916-Methoxy-2-naphthaldehydeHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 27641106-Hydroxy-2-naphthaldehyde수율 37.9%

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

반응 조건

온도
130 °C

실험 절차

Aluminum trichloride (1.07 g, 8.06 mmol) was added to a solution of 6-methoxy-2-naphthaldehyde (1.0 g, 5.37 mmol) in chlorobenzene (15 mL). The reaction mixture was stirred at 130° C. for 4 h. The reaction was quenched with water (5 mL) and conc. HCl (2 mL). The reaction mixture was dissolved in ethyl acetate and washed with water and brine and dried over anhydrous magnesium sulfate. Silica gel chromatography eluting with 10% ethyl acetate/hexane yielded 0.35 g of desired product: ESI-MS173.0 (M+H).

후처리

  1. customThe reaction was quenched with water (5 mL) and conc. HCl (2 mL)
  2. dissolutionThe reaction mixture was dissolved in ethyl acetate
  3. washwashed with water and brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. washSilica gel chromatography eluting with 10% ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-89c00d81e8fb4583825a73f1263c7bee
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351725B2

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