Sodium Hydroxide → 4-(Cyanomethyl)benzoic acid

HRID 898533노트

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HRID 898533 반응식
[C:1]([CH2:3][C:4]1[CH:14]=[CH:13][C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][CH:5]=1)#[N:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:3][C:4]1[CH:14]=[CH:13][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)#[N:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11989373ethyl 4-(cyanomethyl)benzoate

생성물 1

HCID 2708714-(Cyanomethyl)benzoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 10 g (53 mol) of ethyl 4-cyanomethyl-benzoate and 2.02 mL of a 1 M sodium hydroxide solution in 100 mL of ethanol is refluxed for one hour. Then the reaction solution is evaporated down and the residue is combined with ice water. Concentrated hydrochloric acid is added dropwise to the reaction solution until no more precipitate is formed. The precipitate is filtered off, washed twice with water and dried.

후처리

  1. customThen the reaction solution is evaporated down
  2. additionConcentrated hydrochloric acid is added dropwise to the reaction solution until no more precipitate
  3. customis formed
  4. filtrationThe precipitate is filtered off
  5. washwashed twice with water
  6. customdried

출처 및 근거

ORD 기록
ord-c716151ff7ca41a4ae826ba559d40f79
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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