(4-Pyrrolidin-1-ylmethyl-phenyl)-acetonitrile → 2-[4-(Pyrrolidin-1-ylmethyl)phenyl]ethanamine

HRID 898537노트

반응식

HRID 898537 반응식
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][C:14]#[N:15])=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>[Ni].N>[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH2:15])=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 59598027(4-Pyrrolidin-1-ylmethyl-phenyl)-acetonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 164950372-[4-(Pyrrolidin-1-ylmethyl)phenyl]ethanamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 222Ammonia용매

실험 절차

A reaction mixture of 0.73 g (3.66 mmol) of (4-pyrrolidin-1-ylmethyl-phenyl)-acetonitrile and 0.1 g Raney nickel in 25 mL of methanolic ammonia solution is hydrogenated for 9 hours at 50° C. under 3 bar hydrogen.

출처 및 근거

ORD 기록
ord-0f56c63fc9fc404798924ce5de258170
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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