[2-(3-Chloro-4-nitrophenoxy)ethyl]diethylamine → [2-(3-Chloro-4-aminophenoxy)ethyl]diethylamine

HRID 898540노트

반응식

HRID 898540 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[N+:16]([O-])=O)[O:5][CH2:6][CH2:7][N:8]([CH2:11][CH3:12])[CH2:9][CH3:10]>[Ni].CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([O:5][CH2:6][CH2:7][N:8]([CH2:11][CH3:12])[CH2:9][CH3:10])[CH:13]=[CH:14][C:15]=1[NH2:16]

참가 물질

4

반응물 1

HCID 68816613[2-(3-Chloro-4-nitrophenoxy)ethyl]diethylamine

생성물 1

HCID 57082476[2-(3-Chloro-4-aminophenoxy)ethyl]diethylamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8857Ethyl Acetate용매

실험 절차

A suspension of 1.24 g (4.547 mmol) [2-(3-chloro-4-nitro-phenoxy)-ethyl]diethyl-amine (Z27a) and 300 mg Raney nickel in EtOAc was hydrogenated at RT and 3 bar. The catalyst was filtered off and the filtrate evaporated down i. vac.

후처리

  1. customwas hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated down i

출처 및 근거

ORD 기록
ord-54eabcce50c24f09a57bf0eab15f9a0e
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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