(2,4-Dichlorophenoxy)acetyl chloride → 2-(2,4-Dichloro-phenoxy)-n-[4-(2-diethylamino-ethoxy)-3-methoxy-phenyl]-acetamide

HRID 898557

반응식

HRID 898557 반응식
[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6](Cl)=[O:7].[CH2:14]([N:16]([CH2:29][CH3:30])[CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][C:21]=1[O:27][CH3:28])[CH3:15].C(N(C(C)C)C(C)C)C>ClCCl>[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([NH:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH2:17][N:16]([CH2:29][CH3:30])[CH2:14][CH3:15])=[C:21]([O:27][CH3:28])[CH:22]=1)=[O:7]

참가 물질

5

반응물 3

HCID 69887(2,4-Dichlorophenoxy)acetyl chlorideHCID 81531DiisopropylethylamineHCID 224961344-(2-Diethylaminoethoxy)-3-methoxyphenylamine

생성물 1

HCID 129974422-(2,4-Dichloro-phenoxy)-n-[4-(2-diethylamino-ethoxy)-3-methoxy-phenyl]-acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 70 mg (0.290 mmol) of (2,4-dichloro-phenoxy)-acetylchloride in 0.5 mL dichloromethane was added to a solution of 66 mg (0.278 mmol) of 4-(2-diethylamino-ethoxy)-3-methoxy-phenylamine (intermediate product Z6b) and 96 μL (0.56 mmol) of ethyl-diisopropylamine in 1.5 mL abs. dichloromethane and the mixture was stirred for 15 hours at RT. The reaction mixture was evaporated down i. vac. and the residue was purified by column chromatography (silica gel, dichloromethane/MeOH 9:1).

후처리

  1. customThe reaction mixture was evaporated down i
  2. customand the residue was purified by column chromatography (silica gel, dichloromethane/MeOH 9:1)

출처 및 근거

ORD 기록
ord-5c6dc6a4ad93421fae363aea205c7220
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

연결된 노트

불러오는 중…