Potassium Carbonate → 1-(2-Chloro-4-nitro-benzyl)-pyrrolidine

HRID 898586노트

반응식

HRID 898586 반응식
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[Cl:18].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C.ClCCl>[Cl:18][C:10]1[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:9]=1[CH2:8][N:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 30163681-(Bromomethyl)-2-chloro-4-nitrobenzene

생성물 1

HCID 576632361-(2-Chloro-4-nitro-benzyl)-pyrrolidine

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 6344Dichloromethane용매

실험 절차

10.50 g (74.452 mmol) potassium carbonate was added to a solution of 7.400 g (29.543 mmol) of 1-bromomethyl-2-chloro-4-nitro-benzene and 5.00 mL (59.300 mmol) pyrrolidine in 150 mL acetonitrile and the mixture was stirred for 16 h at RT. The reaction mixture was diluted with 200 mL dichloromethane, filtered and the filtrate evaporated down i. vac. The residue was taken up in EtOAc, the org. phase was washed with water, dried over magnesium sulphate and evaporated down i. vac. The crude product was used in the next reaction step without any further purification.

후처리

  1. filtrationfiltered
  2. customthe filtrate evaporated down i
  3. washphase was washed with water
  4. dry with materialdried over magnesium sulphate
  5. customevaporated down i
  6. customThe crude product was used in the next reaction step without any further purification

출처 및 근거

ORD 기록
ord-c84acf0f55b54d35ba4b0b73163d9c1b
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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