1-(2-Chloro-4-nitro-benzyl)-pyrrolidine → 3-Chloro-4-pyrrolidin-1-ylmethyl-phenylamine

HRID 898587노트

반응식

HRID 898587 반응식
[Cl:1][C:2]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1>[Ni].CO>[Cl:1][C:2]1[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1

참가 물질

4

반응물 1

HCID 576632361-(2-Chloro-4-nitro-benzyl)-pyrrolidine

생성물 1

HCID 287218273-Chloro-4-pyrrolidin-1-ylmethyl-phenylamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A suspension of 1.00 g (4.155 mmol) 1-(2-chloro-4-nitro-benzyl)-pyrrolidine (140a) and 100 mg Raney nickel in 30 mL MeOH were hydrogenated at RT and 10 psi. The catalyst was filtered off and the filtrate evaporated down i. vac.

후처리

  1. customwere hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated down i

출처 및 근거

ORD 기록
ord-4d2e7e4ba93d4199ad52f7f75f41af8e
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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