(E)-3-(4'-chlorobiphenyl-4-yl)-N-(4-piperidin-1-ylmethylphenyl)acrylamide → 3-(4'-Chloro-biphenyl-4-yl)-n-(4-piperidin-1-ylmethyl-phenyl)-propionamide

HRID 898619노트

반응식

HRID 898619 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:21][CH:20]=3)=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1>[Ni].CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:21][CH:20]=3)=[O:17])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 9980157(E)-3-(4'-chlorobiphenyl-4-yl)-N-(4-piperidin-1-ylmethylphenyl)acrylamide

생성물 1

HCID 596915573-(4'-Chloro-biphenyl-4-yl)-n-(4-piperidin-1-ylmethyl-phenyl)-propionamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8857Ethyl Acetate용매

실험 절차

A suspension of 0.200 g (0.464 mmol) (E)-3-(4′-chloro-biphenyl-4-yl)-N-(4-piperidin-1-ylmethyl-phenyl)-acrylamide (Example 172) and 100 mg Raney nickel in 50 mL EtOAc was hydrogenated at RT and 50 psi. The catalyst was filtered off, the filtrate was evaporated down i. vac. and the residue was triturated with ether. The precipitate was filtered off, washed with ether and dried at 50° C. i. vac.

후처리

  1. customwas hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate was evaporated down i
  4. customand the residue was triturated with ether
  5. filtrationThe precipitate was filtered off
  6. washwashed with ether
  7. customdried at 50° C. i

출처 및 근거

ORD 기록
ord-41e9c4842206472690400c5b667e3bb9
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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