Methanol → 4-(2,2,4,4-Tetramethyl-8-prop-2-ynyl-chroman-6-ylethynyl)-phenyl-acetic acid

HRID 898679노트

반응식

HRID 898679 반응식
C[O:2][C:3](=[O:34])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:14]=[C:15]3[C:20](=[C:21]([CH2:23][C:24]#[C:25][Si](C)(C)C)[CH:22]=2)[O:19][C:18]([CH3:31])([CH3:30])[CH2:17][C:16]3([CH3:33])[CH3:32])=[CH:7][CH:6]=1.CO.O1CCCC1.O.[OH-].[Li+]>O>[CH3:30][C:18]1([CH3:31])[CH2:17][C:16]([CH3:32])([CH3:33])[C:15]2[C:20](=[C:21]([CH2:23][C:24]#[CH:25])[CH:22]=[C:13]([C:12]#[C:11][C:8]3[CH:7]=[CH:6][C:5]([CH2:4][C:3]([OH:34])=[O:2])=[CH:10][CH:9]=3)[CH:14]=2)[O:19]1

참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 69216503HCID 69216503, 화합물2회

생성물 1

HCID 102873324-(2,2,4,4-Tetramethyl-8-prop-2-ynyl-chroman-6-ylethynyl)-phenyl-acetic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Following general procedure K and using {4-[2,2,4,4-tetramethyl-8-(3-trimethylsilanyl-prop-2-ynyl)-chroman-6-ylethynyl]-phenyl}-acetic acid methyl ester (Compound 48, 0.105 g, 0.21 mmol), methanol (3 mL), tetrahydrofuran (3 mL), water (1.5 mL) and lithium hydroxide monohydrate (0.128 g, 3.07 mmol), the title compound was obtained as a pale yellow solid (0.077 g, 95%). 1H NMR (300 MHz, CDCl3): δ7.51 (d, 1H, J=2.2 Hz), 7.49 (d, 2H, J=8.2 Hz), 7.39 (d, 1H, J=2.2 Hz), 7.25 (d, 2H, J=8.2 Hz), 3.66 (s, 2H), 3.52 (d, 2H, J=2.6 Hz), 2.61 (t, 1H, J=2.6 Hz), 1.83 (s, 2H), 1.36 (s, 6H), 1.35 (s, 6H).

출처 및 근거

ORD 기록
ord-7b89d6a853594c888727bbbb854db39b
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351737B2

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