Hydrochloric Acid → 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride
반응식
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.C(OCC)(=O)C.[ClH:28]>C(OCC)C>[ClH:28].[N:19]1[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:17][CH:18]=1참가 물질
5
실험 절차
Alternatively, 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine (1.0 g, 3.43 mmol) was dissolved in ethyl ether. Ethyl acetate (15 mL) saturated with HCl was added, and the mixture stirred for 30 min at room temperature. The mixture was concentrated under vacuum and provided 1-[2-(4-pyridinyl)-ethyl]piperazine hydrochloride (900 mg, 87%) as a tan solid.
후처리
- concentrationThe mixture was concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-d47d6797a275408f8d4964aa94422349
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07351822B2
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