Hydrochloric Acid → N-[3-(4-Cyanophenyl)propyl]-N-[2-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]methanesulfonamide, hydrochloride salt

HRID 899119노트

반응식

HRID 899119 반응식
C(OC([N:8]1[CH2:15][CH:14]2[O:16][CH:10]([CH2:11][N:12]([CH2:17][CH2:18][N:19]([CH2:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=3)[S:20]([CH3:23])(=[O:22])=[O:21])[CH2:13]2)[CH2:9]1)=O)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[C:33]([C:30]1[CH:31]=[CH:32][C:27]([CH2:26][CH2:25][CH2:24][N:19]([CH2:18][CH2:17][N:12]2[CH2:13][CH:14]3[O:16][CH:10]([CH2:9][NH:8][CH2:15]3)[CH2:11]2)[S:20]([CH3:23])(=[O:22])=[O:21])=[CH:28][CH:29]=1)#[N:34]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 690720537-(2-{[3-(4-Cyanophenyl)propyl]methanesulfonylamino}ethyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester

생성물 1

HCID 69077585N-[3-(4-Cyanophenyl)propyl]-N-[2-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]methanesulfonamide, hydrochloride salt

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

7-(2-{[3-(4-cyanophenyl)propyl]methanesulfonylamino}ethyl)-9-oxa-3,7-di-azabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (3.8 g, 0.0095 mol; see step (i) above) was added to a saturated solution of HCl(g) in ethyl acetate (50 mL) and the resultant mixture was then stirred overnight. On completion of the reaction (as determined by TLC), ethyl acetate was decanted and the product was dried under high vacuum to give the title compound. Yield: 1.5 g (54%).

후처리

  1. customwas decanted
  2. customthe product was dried under high vacuum

출처 및 근거

ORD 기록
ord-409804f3bba5495a8605586aa564ed97
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07354917B2

반응 노트

불러오는 중…