Lithium Hydroxide → 2-(2,1,3-Benzoxadiazol-5-yloxy)nicotinic acid
반응식
C([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][C:6]=1[O:11][C:12]1[CH:20]=[CH:19][C:15]2=[N:16][O:17][N:18]=[C:14]2[CH:13]=1)C.[Li+].[OH-]>O1CCCC1>[N:16]1[O:17][N:18]=[C:14]2[CH:13]=[C:12]([O:11][C:6]3[N:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4]([OH:21])=[O:3])[CH:20]=[CH:19][C:15]=12참가 물질
4
실험 절차
A mixture of 2.2 g (7.7 mmol) 2-[benzo[2,1,3]oxadiazol-5-yloxy]-nicotinic acid ethyl ester and 23.1 ml (23.1 mmol) 1M LiOH in 75 ml tetrahydrofuran was stirred overnight at room temperature. The tetrahydrofuran was evaporated in vacuo and the aqueous mixture was then acidified with 1N HCl. The resulting precipitate was filtered and dried to give 1.9 g (96%) solid.
후처리
- customThe tetrahydrofuran was evaporated in vacuo
- filtrationThe resulting precipitate was filtered
- customdried
출처 및 근거
- ORD 기록
- ord-06df262b88274a9eb58e0928ef34f19c
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07354941B2
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