Acetic Anhydride → HCID 178475126, 화합물

HRID 899418노트

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HRID 899418 반응식
[CH3:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH:11]=[N:12][NH:13][C:14]([NH2:16])=[S:15])[CH:9]=2)[NH:4][N:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([NH:16][C:14](=[N:13]/[N:12]=[CH:11]/[C:8]1[CH:9]=[C:10]2[C:2]([CH3:1])=[N:3][NH:4][C:5]2=[N:6][CH:7]=1)[SH:15])(=[O:19])[CH3:18]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 178434443HCID 178434443, 화합물

생성물 1

HCID 178475126HCID 178475126, 화합물

반응 조건

온도
80 °C

실험 절차

The staring material 1-((3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methylene)thiosemicarbazide (500 mg, 2.0 mmol) and acetic anhydride (20 ml) was mixed and heated to 80° C. for 1 hour. The reaction mixture was then cooled down to room temperature. The yellow solid was precipitated out and was filtered off. The yellow solid was washed with ether (50 ml). The product was obtained in quantitative yield and used for the next step without further purification.

후처리

  1. temperatureThe reaction mixture was then cooled down to room temperature
  2. customThe yellow solid was precipitated out and
  3. filtrationwas filtered off
  4. washThe yellow solid was washed with ether (50 ml)
  5. customThe product was obtained in quantitative yield
  6. customused for the next step without further purification

출처 및 근거

ORD 기록
ord-89f23f75c9004a259fc5c6b7252ec4b2
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07354944B2

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