4-Pyridinecarboxaldehyde → (s)-5-Methyl-1-pyrid-4-ylmethyl-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate
반응식
[NH:1]([C:8](OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=[O:9])[C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][OH:4].[N:25]1[CH:30]=[CH:29][C:28]([CH:31]=O)=[CH:27][CH:26]=1.[F:33][C:34]([F:46])([F:45])[S:35]([C:38]1[CH:44]=[CH:43][C:41]([NH2:42])=[CH:40][CH:39]=1)(=[O:37])=[O:36]>>[F:33][C:34]([F:46])([F:45])[C:5]([OH:7])=[O:6].[CH3:5][C@@H:2]1[N:1]([CH2:31][C:28]2[CH:27]=[CH:26][N:25]=[CH:30][CH:29]=2)[C:8](=[O:9])[N:42]([C:41]2[CH:43]=[CH:44][C:38]([S:35]([C:34]([F:45])([F:33])[F:46])(=[O:36])=[O:37])=[CH:39][CH:40]=2)[C:3]1=[O:4]참가 물질
4
반응물 3
생성물 1
실험 절차
The compound is prepared from 0.025 mmol of resin, 0.075 mmol of N-Fmoc-L-Ala(OH), 0.125 mmol of 4-pyridinecarboxaldehyde and 0.0625 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 5.6 mg of expected product are obtained.