N-Iodosuccinimide → HCID 178470396, 화합물

HRID 900233노트

반응식

HRID 900233 반응식
[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2].C1C(=O)N([I:19])C(=O)C1>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([I:19])=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 178470400HCID 178470400, 화합물

생성물 1

HCID 178470396HCID 178470396, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 5 g 5-Methyl-3H-imidazole-4-carboxylic acid ethyl ester and 7.2 g NIS in 50 ml THF were refluxed for 10 h. After cooling, the solvent was removed under reduced pressure and the residue taken-up in ethyl acetate, washed with sat. NaS2O3 solution and dried over MgSO4. After removal of the solvent under reduced pressure the product was purified by recrystallisation from ethyl acetate. Yield: 7 g

후처리

  1. temperatureAfter cooling
  2. customthe solvent was removed under reduced pressure
  3. washthe residue taken-up in ethyl acetate, washed with sat. NaS2O3 solution
  4. dry with materialdried over MgSO4
  5. customAfter removal of the solvent under reduced pressure the product
  6. customwas purified by recrystallisation from ethyl acetate

출처 및 근거

ORD 기록
ord-cc9326ec9b034b019e7134ef7508ca68
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07358268B2

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