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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

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Trichloroacetyl chloride → 1-(3-Methoxy-benzyl)-1H-imidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

HRID 900252

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HRID 900252 반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[CH:8]1.CCN(CC)CC.ClC(Cl)(Cl)[C:24](Cl)=[O:25].[CH:29]([N:32]1[CH2:37][CH2:36][CH:35]([NH2:38])[CH2:34][CH2:33]1)([CH3:31])[CH3:30]>C(Cl)Cl>[CH:29]([N:32]1[CH2:37][CH2:36][CH:35]([NH:38][C:24]([C:8]2[N:7]([CH2:6][C:5]3[CH:12]=[CH:13][CH:14]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:11]=[CH:10][N:9]=2)=[O:25])[CH2:34][CH2:33]1)([CH3:31])[CH3:30]

참가 물질 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

6

반응물 4

HCID 6420Trichloroacetyl chloride

HCID 8471Triethylamine2회

HCID 31633331-(Propan-2-yl)piperidin-4-amine

HCID 122293911-(3-methoxy-benzyl)-1H-imidazole

생성물 1

HCID 104059941-(3-Methoxy-benzyl)-1H-imidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

시약·촉매·용매 1

HCID 6344

Dichloromethane

용매

실험 절차

To a solution of 1-(3-methoxy-benzyl)-1H-imidazole (100 mg) and NEt3 (147 μL) in DCM (5 mL) was added trichloroacetyl chloride (106 μL) dropwise. The mixture was stirred for 2 h at RT. More NEt3 (147 μL) and 1-isopropyl-piperidin-4-ylamine (76 mg) were added and stirring was continued for 1 h at RT. The mixture was quenched by the addition of MeOH, concentrated and the residue was purified by preparative HPLC. The fractions containing the product were evaporated to provide 30 mg of the title compound as its trifluoroacetate salt. MS (ESI+): m/e=357.

후처리

stirringstirring
waitwas continued for 1 h at RT
customThe mixture was quenched by the addition of MeOH
concentrationconcentrated
customthe residue was purified by preparative HPLC
additionThe fractions containing the product
customwere evaporated

출처 및 근거

ORD 기록: ord-2176587afdc241b88c9ae1bfea7a4413
출처 데이터셋: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07358268B2

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