Hydrochloric Acid → (4,5-Dichloro-1H-imidazol-2-yl)methanol

HRID 900750노트

반응식

HRID 900750 반응식
[OH-:1].[K+].[Cl:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[Cl:9].[CH2:10]=O.Cl>O>[Cl:3][C:4]1[N:5]=[C:6]([CH2:10][OH:1])[NH:7][C:8]=1[Cl:9]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 14797Potassium HydroxideHCID 1400184,5-Dichloroimidazole

생성물 1

HCID 17974733(4,5-Dichloro-1H-imidazol-2-yl)methanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Potassium hydroxide (0.12 g, 2.14 mmol) in water (4 ml) was added to 4,5-dichloroimidazole, and the suspension was stirred for 35 min. Paraformaldehyde (0.11 g, 3.66 mmol) was added portionwise and the reaction mixture was stirred over night, then acidified with dilute HCl to pH 1 and then concentrated in vacuo to give a white solid, 0.6 g (98%).

후처리

  1. stirringthe reaction mixture was stirred over night
  2. concentrationconcentrated in vacuo
  3. customto give a white solid, 0.6 g (98%)

출처 및 근거

ORD 기록
ord-bf606cbed2f74542bad9de68bf2a5821
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07361660B2

반응 노트

불러오는 중…