4-Isopropylaniline → HCID 178439243, 화합물

HRID 901902

반응식

HRID 901902 반응식
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH:13]([C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)([CH3:15])[CH3:14]>>[CH:13]([C:16]1[CH:22]=[CH:21][C:19]([NH:20][C:9]([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:12][CH:11]=2)=[NH:10])=[CH:18][CH:17]=1)([CH3:15])[CH3:14]

참가 물질

3

반응물 2

HCID 74644-IsopropylanilineHCID 5199814-(Methylsulfonyl)benzonitrile

생성물 1

HCID 178439243HCID 178439243, 화합물수율 60%

실험 절차

The title compound was prepared from 4-methylsulfonylbenzonitrile (5.43 g, 30 mmol) and 4-isopropylaniline (4.05 g, 30 mmol) by following the procedure described in preparation 1 (5.66 g, yield 60%, purity 88% by HPLC). 1H-NMR (CDCl3):δ 1.25-1.27 (d, 6H), 2.9-2.95 (m, 1H), 3.07 (s, 3H), 4.92 (bs, 2H, D2O exchangeable), 6.90-6.92 (d, 2H), 7.23-7.26 (d, 2H), 8.01-8.03 (d, 2H), 8.08-8.1 (d, 2H). MS m/z:317.2 (M+).

후처리

  1. customdescribed in preparation 1 (5.66 g, yield 60%, purity 88% by HPLC)

출처 및 근거

ORD 기록
ord-0bfd268215da41f79ebf9c3bf0464de5
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365069B2

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