Hydrochloric Acid → 3-(Piperidin-4-yl)propan-1-ol hydrochloride
반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:3][CH:2]=1.[ClH:11]>[Pt]=O>[ClH:11].[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][OH:10])[CH2:3][CH2:2]1참가 물질
4
실험 절차
1.00 g (7.29 mmol) of 4-pyridinepropanol was dissolved in 3N aqueous hydrochloric acid solution and 206 mg of platinum oxide was added thereto, followed by stirring of the mixture at room temperature under a hydrogen atmosphere at an ordinary pressure for 12 hours. The reaction mixture was filtered with Celite and the filtrate was distilled off under reduced pressure. The thus obtained residue was reprecipitated from methanol-ether to obtain 1.31 g (yield: quantitative) of the title compound as a white solid.
후처리
- filtrationThe reaction mixture was filtered with Celite
- distillationthe filtrate was distilled off under reduced pressure
- customThe thus obtained residue was reprecipitated from methanol-ether
출처 및 근거
- ORD 기록
- ord-4b60620bf83045789194e22f531affcb
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07365067B2
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