Water → 1,2-Bis(p-chlorophenyl) ethanol

HRID 902105

반응식

HRID 902105 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[BH4-].[Na+].O>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:17])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 5873181,2-Bis(4-chlorophenyl)ethanoneHCID 4311764Sodium borohydride

생성물 1

HCID 420561,2-Bis(p-chlorophenyl) ethanol

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
0 °C

실험 절차

A solution of 1,2-di(4-chlorophenyl)ethan-1-one (known compound) and sodium borohydride in methanol is stirred at ambient temperature for about three hours. After this time, the reaction mixture is cooled, and water is carefully added to destroy excess sodium borohydride. The mixture is cooled to 0° C. and neutralized with concentrated hydrochloric acid. The mixture is concentrated under reduced pressure to remove some of the methanol. The concentrate is taken up in ethyl acetate and washed with an aqueous solution saturated with sodium chloride. The organic layer is dried with sodium sulfate, filtered, and concentrated under reduced pressure, yielding the subject compound.

후처리

  1. temperatureAfter this time, the reaction mixture is cooled
  2. customto destroy excess sodium borohydride
  3. concentrationThe mixture is concentrated under reduced pressure
  4. customto remove some of the methanol
  5. washwashed with an aqueous solution saturated with sodium chloride
  6. dry with materialThe organic layer is dried with sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customyielding the subject compound

출처 및 근거

ORD 기록
ord-896f01023e9145459af97ff114d04b33
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365082B2

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