Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Gamma-Butyrolactone → Pyrrolidinone, (4-aminophenyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Gamma-Butyrolactone | HCID 7302 | — |
| 반응물 | P-Phenylenediamine | HCID 7814 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | Pyrrolidinone, (4-aminophenyl)- | HCID 676146 | — |
반응 단계
800 mg Benzene-1,4-diamine and 600 μl Dihydro-furan-2-one were heated for 1 h to 200° C. under microwave irradiation (200 W, CEM Discover™ apparatus). Finally, 10 mL saturated NaHCO3 solution were added and the mixture was directly purified by chromatography on silica gel eluting with a gradient of DCM/MeOH 100%->50%. The fractions containing the product were combined and the solvent evaporated under reduced pressure. Yield: 860 mg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07365088B2 |
| 출처 데이터셋 | uspto-grants-2008_04 |
| ORD ID | ord-4327214eb5274d1ea3ad9d089429ea25 |
| 출처 메모 | uspto-grants-2008_04 |