Water → [3-(Butylamino)phenyl]methanol

HRID 902236

반응식

HRID 902236 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].C([O-])(O)=O.[Na+].Br[CH2:16][CH2:17][CH2:18][CH3:19].O>CS(C)=O>[CH2:16]([NH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH2:5][OH:6])[CH:3]=1)[CH2:17][CH2:18][CH3:19]

참가 물질

6

반응물 4

HCID 962WaterHCID 8002Butyl bromideHCID 802933-Aminobenzyl alcoholHCID 516892Sodium Bicarbonate

생성물 1

HCID 22322603[3-(Butylamino)phenyl]methanol

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
50 °C

실험 절차

To a solution of 3.69 g (30 mmol) of 3-amino benzyl alcohol in 20 ml DMSO was added 3.78 g (45 mmol) solid NaHCO3 and 2.91 ml (27 mmol) 1-bromobutane. The reaction was allowed to stir at 50° C. for 18 hours (overnight). Reaction was worked up by adding 250 ml water and product was extracted in ethyl acetate. Water was added, and the resultant mixture was extracted with EtOAc. The organic layer was washed with water and brine.

후처리

  1. customReaction
  2. extractionwas extracted in ethyl acetate
  3. additionWater was added
  4. extractionthe resultant mixture was extracted with EtOAc
  5. washThe organic layer was washed with water and brine

출처 및 근거

ORD 기록
ord-ede483588b7f43ec914b02a6faa03a8e
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365093B2

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