Sodium Hydroxide → 7-Bromo-2-methyl-2H-indazole-3-carboxylic acid

HRID 902562노트

반응식

HRID 902562 반응식
C[O:2][C:3]([C:5]1[N:6]([CH3:15])[N:7]=[C:8]2[C:13]=1[CH:12]=[CH:11][CH:10]=[C:9]2[Br:14])=[O:4].[OH-].[Na+]>C(O)C>[Br:14][C:9]1[C:8]2[C:13](=[C:5]([C:3]([OH:4])=[O:2])[N:6]([CH3:15])[N:7]=2)[CH:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58861011Methyl 7-bromo-2-methyl-2H-indazole-3-carboxylate

생성물 1

HCID 210946187-Bromo-2-methyl-2H-indazole-3-carboxylic acid수율 94.7%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
55 °C

실험 절차

A mixture of 7-bromo-2-methyl-2H-indazole-3-carboxylic acid methyl ester (35a; 0.215 g, 0.799 mmol), 8 mL of a 2 M aqueous NaOH solution, and 6 mL of ethanol was stirred at 55° C. overnight, then concentrated to remove ethanol. The remaining aqueous layer was acidified with a 10% aqueous HCl solution and extracted with three 20 mL portions of ethyl acetate. The combined organic layers were dried over Na2SO4, filtered, and concentrated to afford crude 7-bromo-2-methyl-2H-indazole-3-carboxylic acid (35e; 0.193 g; 94%) which was used without further purification.

후처리

  1. concentrationconcentrated
  2. customto remove ethanol
  3. extractionextracted with three 20 mL portions of ethyl acetate
  4. dry with materialThe combined organic layers were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c6abcbab167842aeb8d8f4134623e77c
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365211B2

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