1-Methylpiperazine → HCID 178480672, 화합물

HRID 902650노트

반응식

Cl[C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[CH3:9][N:10]1[CH2:15][CH2:14][N:13]([C:2]2[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=2)[CH2:12][CH2:11]1

참가 물질

반응물 2

HCID 531671-Methylpiperazine

HCID 178516025CID 5284509

생성물 1

HCID 178480672HCID 178480672, 화합물수율 66%

반응 조건

온도: 90 °C

실험 절차

To a stirring solution of 1-methyl-piperazine (10 ml) was added 6-chloro-2-pyridinol (1.5 g, 11.57 mmol) and the mixture was heated at 90° C. for 60 h. The reaction mixture was cooled to RT and concentrated under reduced pressure (while heating) to afford the title compound as a brown solid (66%). The crude material was used without further purification. MS (ESI) 194.2 (M+H+).

후처리

temperatureThe reaction mixture was cooled to RT
concentrationconcentrated under reduced pressure (while heating)

출처 및 근거

ORD 기록: ord-6a0c3e8b61c94e06bbf0cae4be762cc4
출처 데이터셋: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07365085B2

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