Potassium Sodium Tartrate → N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine

HRID 902724노트

반응식

HRID 902724 반응식
[Cl:1][C:2]1[C:20]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][NH:5][C:6](=O)[CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])[CH3:8].[H-].C([Al+]CC(C)C)C(C)C.[C@H](O)(C([O-])=O)[C@@H](O)C([O-])=O.[Na+].[K+]>C1(C)C=CC=CC=1.CCCCCC.CCOCC>[Cl:1][C:2]1[C:20]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][NH:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])[CH3:8]

참가 물질

7

반응물 3

HCID 9357Potassium Sodium TartrateHCID 21225700DiisobutylaluminumhydrideHCID 69254638N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide

생성물 1

HCID 69252183N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine

시약·촉매·용매 3

HCID 1140Toluene용매HCID 3283Diethyl Ether용매HCID 8058Hexane용매

실험 절차

A solution of N-(2-chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide (265 mg, 0.7 mmole) in 40 mL of toluene was treated with diisobutyl aluminum hydride (5 mL of a 1N solution in hexane), and the reaction was stirred for 90 minutes. The reaction was diluted with 20 mL of Et2O, a concentrated aqueous solution of Rochelle salt was added, and the mixture stirred for 60 minutes, at which time the emulsion had broken apart. The organic layer was separated, washed with H2O, aqueous Rochelle salt, dried and the solvent removed, and gave the titled compound, 221 mg (87%). MS (ESI) 362 (MH+).

후처리

  1. stirringthe mixture stirred for 60 minutes, at which time the emulsion
  2. customThe organic layer was separated
  3. washwashed with H2O, aqueous Rochelle salt
  4. customdried
  5. customthe solvent removed

출처 및 근거

ORD 기록
ord-c08b500b8b534aef85b5c6e605de45b8
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365085B2

반응 노트

불러오는 중…