Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 902856생성일: 2026년 10월 25일
Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → (S,E)-tert-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-2,2-dimethyloxazolidine-3-carboxylate
https://huagongshe.com/reaction/902856
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| 반응물 | 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- | HCID 178792 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (S,E)-tert-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-2,2-dimethyloxazolidine-3-carboxylate | HCID 10732902 | 111.3% |
반응 단계
A mixture solution composed of tert-Butyl (4R)-4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (11.7 g), (carboethoxymethylene)triphenylphosphorane (20.7 g) and toluene (100 ml) was heated and stirred at 100° C. for 18 hours. The reaction mixture was concentrated, and the resultant residue was purified by column chromatography on silica gel (hexane:ethyl acetate=8:1) to obtain the title compound (17 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07365205B2 |
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| 출처 데이터셋 | uspto-grants-2008_04 |
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| ORD ID | ord-bd1fe807fde940a5aeac8434d03b5d1b |
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| 출처 메모 | uspto-grants-2008_04 |
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