反应详情

温度

100 °C

A mixture solution composed of tert-Butyl (4R)-4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (11.7 g), (carboethoxymethylene)triphenylphosphorane (20.7 g) and toluene (100 ml) was heated and stirred at 100° C. for 18 hours. The reaction mixture was concentrated, and the resultant residue was purified by column chromatography on silica gel (hexane:ethyl acetate=8:1) to obtain the title compound (17 g).

1. temperaturewas heated
2. concentrationThe reaction mixture was concentrated
3. customthe resultant residue was purified by column chromatography on silica gel (hexane:ethyl acetate=8:1)