Hydrochloric Acid → HCID 15313948, 화합물

HRID 903116노트

반응식

HRID 903116 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14](N)=[O:15].Cl.[C:21](=O)(O)[O-:22].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([O:22][CH3:21])=[O:15]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 233376972-(2-Chloro-4-trifluoromethylphenylamino)-3-methylbutyramide

생성물 1

HCID 15313948HCID 15313948, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutyramide (1 mmol) and 4 ml of methanol, saturated with HCl gas, is heated at 75° for about 40 hours. The mixture is cooled, poured into saturated aqueous sodium bicarbonate and extracted with ether. The combined ether extracts are dried over sodium sulfate and solvent removed in vacuo to yield methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, which can be further purified by prep. thin layer chromatography.

후처리

  1. temperatureThe mixture is cooled
  2. extractionextracted with ether
  3. dry with materialThe combined ether extracts are dried over sodium sulfate and solvent
  4. customremoved in vacuo

출처 및 근거

ORD 기록
ord-4eef25e6ba7e4adaa88d56cebb91a18c
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04226802

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