Methyl Isocyanate → Fluzinamide

HRID 903132노트

반응식

HRID 903132 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH:7]1[CH2:10][NH:9][CH2:8]1.[CH3:16][N:17]=[C:18]=[O:19]>C1C=CC=CC=1>[CH3:16][NH:17][C:18]([N:9]1[CH2:10][CH:7]([O:6][C:5]2[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:1])([F:14])[F:15])[CH:4]=2)[CH2:8]1)=[O:19]

참가 물질

4

반응물 2

HCID 12228Methyl IsocyanateHCID 111385383-[3-(Trifluoromethyl)phenoxy]azetidine

생성물 1

HCID 53467Fluzinamide

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To 6.0 g. (0.024 mole) of 3-(3-trifluoromethylphenoxy) azetidine in 50 ml. of dry benzene was added dropwise 1.37 g. (0.024 mole) of methylisocyanate with stirring, and stirring was continued for 30 minutes. The solid which crystallized in the flask was recrystallized using 95% ethanol to give 5.0 g. (76%) of product (m.p. 145°-147° C.).

후처리

  1. customThe solid which crystallized in the flask
  2. customwas recrystallized
  3. customto give 5.0 g

출처 및 근거

ORD 기록
ord-868b300370dd4c3f90fca1ffe2ead79d
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04226861

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