Methyl Isocyanate → N-Methyl 3-(3-aminocarbonylphenoxy)-1-azetidinecarboxamide
반응식
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:11])=[O:10])[CH2:2]1.[CH3:15][N:16]=[C:17]=[O:18]>C1C=CC=CC=1>[CH3:15][NH:16][C:17]([N:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:14]=[CH:13][CH:12]=[C:8]([C:9]([NH2:11])=[O:10])[CH:7]=2)[CH2:2]1)=[O:18]참가 물질
4
실험 절차
To a stirring solution of 7.0 g. (0.036 mole) of 3-(3-azetidinyloxy)benzamide in 75 ml. of dry benzene was slowly added 2.0 g. (0.036 mole) of methylisocyanate. Stirring was continued at room temperature for one hour. The solid which separated was filtered and recrystallized from 60% ethanol. The product weighed 6.0 g. (67%) and melted at 238°-240° C.
후처리
- customThe solid which separated
- filtrationwas filtered
- customrecrystallized from 60% ethanol
출처 및 근거
- ORD 기록
- ord-ef6347e3bf174c59a1cc80fab2a4d170
- 출처 데이터셋
- uspto-grants-1980_10
- 특허 번호
- US04226861
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